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These mechanisms that reduce hunger are: the suppression of orexigenic peptides, the increase in energy expenditure, by activating basal metabolism and body temperature (thus burning energy reserves), the reduction of lipogenesis (the formation of new fats), activation of lipolysis of triglycerides and beta oxidation of the resulting fatty acids. The functioning of leptin is actually negative feedback, that is, when the hypothalamus detects enough fat reserves, it inhibits intake and anabolism (
Leptin is a hormone that regulates your appetite and the percentage of body fat in your body. It acts as a "lipostat," that is, when the amount of fat stored in adipocytes increases, leptin is released into the bloodstream, informing the hypothalamus and endocrine mechanisms being activated to reduce appetite. With the discovery of leptin in 1994, research began on the hormonal mechanisms involved in appetite regulation, food consumption, storage in adipose tissue, and the development of insulin
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Without going into further medical detail, ghrelin, leptin, and insulin work like switches on a thermostat. For example, in a heater, the thermostat monitors the level of heat in the room.When the room is too cold the thermostat turns on the heater. When the temperature level rises too high, the thermostat turns off the heater and this allows the temperature to drop again. Leptin levels work the same way.https://www.marketwatch.com/press-release/leptoconnect-comprehensive-research-study-2020-r
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